Benjamin Lang
Photo: SCIoI
Benjamin Lang obtained his B.Sc. in Biosciences and his M.Sc. in Molecular Biosciences from Heidelberg University, majoring in Infectious Diseases. Before joining SCIoI in 2020, he carried out his master thesis project at the MRC-Centre for Virus Research in Glasgow, where he investigated the host-response to type III interferons at the single-cell level. While previously using mice as disease models, they now serve as a model organism to study social learning in his doctoral project. The investigation of social learning strategies with respect to the impact of affective states and emotional signaling will lay the basis for the synthetic modeling of social reinforcement learning. At SCIoI, Benjamin works on the Project 25, “Mice Learning in Social Interaction”.
Projects
Benjamin Lang is member of:
Publications +
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date
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19919
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Klenova, A. V., Lang, B., Jaap, A., Thöne-Reineke, C., Lewejohann, L., & Mieske, P. (2026). Female mice in established social groups use different ultrasonic vocalizations during peaceful and aggressive interactions. Behavioural Brain Research, 498, 115904. https://doi.org/10.1016/j.bbr.2025.115904
Andresen, N., Wöllhaf, M., Wilzopolski, J., Lang, A., Wolter, A., Howe-Wittek, L., Bekemeier, C., Pawlak, L.-I., Beyer, S., Cynis, H., Hietel, E., Rieckmann, V., Rieckmann, M., Thöne-Reineke, C., Lewejohann, L., Hellwich, O., & Hohlbaum, K. (2026). Automatic pain face analysis in mice: Applied to a varied dataset with non-standardized conditions. bioRxiv. https://doi.org/10.64898/2026.02.16.706098
Hohlbaum, K., Andresen, N., Mieske, P., Kahnau, P., Lang, B., Diederich, K., Palme, R., Mundhenk, L., Sprekeler, H., Hellwich, O., Thöne-Reineke, C., & Lewejohann, L. (2024). Lockbox enrichment facilitates manipulative and cognitive activities for mice. Open Research Europe, 4, 108. https://doi.org/10.12688/openreseurope.17624.2
Kahnau, P., Mieske, P., Wilzopolski, J., Kalliokoski, O., Mandillo, S., Hölter, S. M., Voikar, V., Amfim, A., Badurek, S., Bartelik, A., Caruso, A., Čater, M., Ey, E., Golini, E., Jaap, A., Hrncic, D., Kiryk, A., Lang, B., Loncarevic-Vasiljkovic, N., … Hohlbaum, K. (2023). A systematic review of the development and application of home cage monitoring in laboratory mice and rats. BMC Biology, 21(1), 256. https://doi.org/10.1186/s12915-023-01751-7
Lang, B., Kahnau, P., Hohlbaum, K., Mieske, P., Andresen, N. P., Boon, M. N., Thöne-Reineke, C., Lewejohann, L., & Diederich, K. (2023). Challenges and advanced concepts for the assessment of learning and memory function in mice. Frontiers in Behavioral Neuroscience, 17, 1230082. https://doi.org/10.3389/fnbeh.2023.1230082
